Does Rapamycin make you look younger?
Sep 6, 2022
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Does Rapamycin make you look younger?

How does Rapamycin make you look younger, run faster and live longer and become stronger? In this blog, you will learn all about Rapamycin. A healthier and longer life means more opportunities for happiness and more time with your loved ones.

History of Rapamycin

Rapamycin was first discovered in 1965 in a fungus found in beer called “Nocardia”. It turns out that this bacterium produces a compound that inhibits cell growth. By studying mice with cancer, Drs. Kennerdell and Wahlberg at Harvard University identified an ingredient in Nocardia that slows tumour growth. They later learned that the same substance slowed skin cell growth when applied externally.

Does Rapamycin make you look younger?

Rapamycin slows ageing in healthy cells while inhibiting growth and metabolism in unhealthy and cancer cells. Cancer cells develop and multiply more quickly than normal healthy cells in our bodies, and as a result, cancer cells frequently outnumber healthy cells.

Rapamycin inhibits and slows the development of cancer cells by targeting certain signals. Rapamycin, as a result, inhibits cancer cell metabolism and is seen as a promising anti-cancer medication.

Two more FDA-approved drugs derived from rapamycin, sirolimus and everolimus, known as "rapalogs," were licenced in 2007 and 2009 for the treatment of advanced kidney cancer.

Since then, numerous research studies have demonstrated that rapamycin and its "rapalogs" are not only useful for treating organ rejection and cancer but are also utilised to treat other chronic medical diseases, including, more recently, ageing.

We can all identify the outward indicators of ageing, such as wrinkled skin, grey hair, and visible bone structures, but what is happening inside our bodies that cause these physical changes? The ageing process can be traced down to our cells.

As we age, biological processes within our cells, together with environmental elements such as sunshine, air pollution, and poisons in our diet, begin to affect the structure and function of our cells.

As we age, our cells' DNA becomes damaged. DNA is the "brain" of the cell, containing all of the information required for our cells to survive and function properly.

The team recruited 13 participants over the age of 40 for the investigation, which took the guise of a clinical trial.

Every 1 or 2 days before bedtime, the participants were instructed to apply rapamycin cream to the back of one hand and a placebo cream to the back of the other hand.

For eight months, the subjects were evaluated every two months. During the appointments, investigators photographed the patients to assess their skin wrinkles and overall look.

The participants also provided blood samples during the 6-month and 8-month visits, as well as a skin biopsy of both hands.

Blood tests revealed that the rapamycin had not entered the subjects' bloodstream.

After 8 months, the majority of the hands that had received rapamycin treatment had an increase in collagen and a decrease in p16 protein.

Collagen is a protein that provides structure to the skin, while p16 is a marker of cellular senescence or degeneration caused by ageing. Skin with more senescent cells is wrinkled.

Skin with higher amounts of p16 is more susceptible to infection and tends to rip and heal more slowly. These are all symptoms of dermal atrophy, a skin disorder common in the elderly.

p16 research has revealed that human cells release the protein as part of a stress response after cell injury. These findings also show that p16 can act as a tumour suppressor, a type of protein that prevents excessive or uncontrolled cell growth and division.

When cells begin to behave improperly, cancer emerges. This can occur as a result of a mutation that causes cell processes to malfunction. P16, as a tumour suppressor, pauses the cell cycle, favouring age rather than malignancy.

Does Rapamycin slow ageing

Scientists believe that using this drug to prevent immune system damage may be an important strategy for extending life expectancy. Because it stimulates a protein called mTOR, which regulates cell growth, metabolism, and survival, rapamycin promotes healthy ageing by preventing age-related loss of function. And rapamycin makes you look younger.

In animal studies, treatment with rapamycin has been shown to increase lifespan. In 2012, NASA announced that male mice treated with rapamycin reached statistical significance for human longevity.

This is just a proof of concept study in mice, but it provides hope that targeting senescence could extend the human health span. It’s also promising because it shows that rapamycin can reduce inflammation and remodel the body’s tissues even at low doses.

However, there are some side effects of rapamycin. It causes weight gain and increases blood pressure due to its immunosuppressive properties. Therefore, patients taking rapamycin should still exercise and eat well to manage these risks.

Scientist's reaction to Rapamycin

Scientists are closely watching whether or not drugs like rapamycin can extend life in humans. Does Rapamycin make you look younger?

Rapamycin is an existing drug that was first discovered in 1965 by Martin Cohen, who also invented it in 1971. It prevents some of your organs from rejecting a transplant.

In recent years, scientists have realized how powerful this drug may be to prevent rejection in organ transplants as well as reduce inflammation and even slow ageing itself.

Last year, researchers published results about giving rapamycin to mice. They found that they could give the rodents the compound for two years without any apparent side effects.

This means it might be possible to give people lifelong doses of rapamycin, with no risks. However, so far, there are still many questions left unanswered. For example, we don’t know if taking rapamycin daily will work for someone every day for the rest of their lives.

It’s also unclear if people would ever need to take it again. These are all things we'll have to keep checking out. But once we do, I suspect we'll start seeing more studies done on human subjects.

Although rapamycin has been shown to extend life in various species, including humans, significant side effects have limited its use.

However, more study is needed to confirm whether it works for slowing ageing in people. Some early research suggests it may be able to improve health and energy levels as well as reduce inflammation and pain.

They also demonstrated that this chemical prevented atherosclerosis (hardening of arteries) in rabbits. Atherosclerosis is what causes heart disease and other problems associated with ageing.

In 1971, they realized that adding a similar chemical to food would prevent animal tumours and atherosclerosis. And in 1972, they proved that eating this stuff extended lifespan. Later, learning from bacteria, they synthesized two related compounds known as rapamycin analogues. One of them, everolimus, is used to treat kidney failure due to injury.

Another one, temsirolimus or sirolimus, is used to prevent organ rejection after transplantation.

Can rapamycin reverse ageing and makes you look younger?

Rapidmomycin is an antibiotic used to prevent bacterial infections in patients who are at high risk for infection. It also reduces pain by lowering levels of inflammation.

It works by blocking part of the cell’s mTOR pathway, which controls cellular growth. When this drug was tested in humans, it reduced inflammation and improved skin quality and thickness in older people with thinning hair.

However, studies show that it did not improve overall health or longevity in these individuals.

Rapalogs are another type of immunosuppressant developed for use with rapamycin. They mimic the effects of rapidmomycin but don’t have as many side effects. However, they still have some side effects and aren’t appropriate for all patients.

They’re most commonly used to treat organ transplant recipients. Other uses include lupus erythematosus, rheumatoid arthritis, and Crohn’s disease.

Scientists are closely studying how mTOR works to see if it can be used to prevent age-related deterioration. So far, they’ve found that it helps maintain or increase health and function in many tissues throughout the body.

Because of this, researchers have been investigating whether targeting mTOR could do the same for cells and organs. Unfortunately, research so far has not yielded very promising results.

However, over the past few years, several studies have started looking at whether using rapamycin (a compound found in bacteria) might help people who suffer from the disease by resetting their bodies' clock.

These studies show that taking rapamycin may be able to restore healthy function to damaged organs and tissue, as well as improve symptoms such as high blood pressure and diabetes.

It also appears to boost anti-ageing genes in humans. In one study, nine overweight and obese men took 2 mg/kg of rapamycin for two weeks. RNA sequencing showed that expression levels of SIRT1, an enzyme that regulates DNA repair and cell survival, increased more than threefold.

Another study conducted gene therapy to express SIRT1 in monocytes (type of white blood cell). The treatment was safe and improved mitochondrial fitness (how efficiently your cells use energy) in young patients with dyslipidemia (high cholesterol and triglyceride levels).

They also saw improvements in muscle strength and exercise performance. Taken together, these findings suggest that.

At what age should you start rapamycin?

For children

For children, pharmacologic immunosuppression with rapamycin can reduce inflammation and inhibit the growth of their immune system. This means that they do not have to be allergic to milk or eggs to receive the medication. Patients receiving this therapy start losing weight due to loss of appetite.

Rapamycin is approved for use in pediatric populations between 2 months and 17 years old. The drug is administered as an oral suspension or by mouth.

Patients who cannot take oral medications are usually started on topical rapamycin which must be applied topically.

When used in children, adverse effects include lymphoma, kidney problems, liver damage, and pulmonary hypertension. When these side effects occur, treatment is less effective. Patients may also experience rejection when transplanted organs fail. Though rare, graft-versus-host disease occurs if someone else’s cells were implanted into them.

For teens

Starting rapamycin earlier is more beneficial for your health. This drug can prevent some cancers and decrease inflammation.

Also, studies show that it can reduce or even eliminate skin ageing by promoting collagen production and cell regeneration. By reducing wrinkles and improving overall texture, it can be used to treat acne and other signs of premature ageing.

By starting rapamycin early in life, you can achieve benefits that may not appear until later in adulthood. However, no long-term studies are looking at the safety of using this medication during childhood and adolescence.

There have been several case reports of patients between the ages of 13 and 17 receiving rapamycin and developing significant complications. Patients were hospitalized with heart problems such as cardiac arrhythmia and low blood pressure. One patient died from refractory ventricular tachycardia (a fast heart rate).

Therefore, while use in children does exist, it is still unknown if these medications are safe. Children should therefore wait to start treatment until they turn 18 years old.

For adults - Rapamycin makes you look younger

Starting rapamycin earlier can reduce the risk of chronic kidney disease, cardiovascular issues, and mortality.

Rapamycin is already approved to treat certain conditions in patients with diabetes or liver problems, as well as those in whom renal transplantation is being considered. It is also used in people who have undergone cardiac bypass surgery and are at high risk for another operation.

In previous trials, it reduced the rate of progression of diabetic nephropathy by about 50% after one year. After three years, it continued to slow the decline in the glomerular filtration rate.

However, recent studies show that treatment may need to be prolonged beyond five years to achieve these benefits. Treatment effectiveness appears to decrease with time.

As such, physicians often recommend continuing therapy indefinitely. This recommendation is supported by data from the RADAR trial, which showed clinical benefit up until 14 years of follow-up.

Although rare, adverse effects including cancer, muscle damage, and thyroid dysfunction have been reported. These include increased risks of bladder cancer and possibly prostate cancer among males taking rapamycin.

Concerns regarding bacterial infections and sepsis make this drug's off-label use in otherwise healthy children unlikely.

For these reasons, it is recommended that age-appropriate immunosuppression begin early (before two months) in infants requiring organ transplants.

Another helpful blog: What is Sirolimus (Rapamycin) and Its Price, Uses, Side-Effects?

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